Description

Tetrahydro-2H-Pyran-4-Carboxylic Acid is a versatile heterocyclic building block and chiral intermediate of significant importance in modern synthetic chemistry. Its rigid, oxygen-containing tetrahydropyran ring structure makes it a valuable scaffold for constructing complex molecules with specific three-dimensional properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for applications in drug discovery, catalyst development, and material science.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Ligand and Catalyst Development: Serves as a foundational unit for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and functional materials where the tetrahydropyran moiety imparts specific solubility or stability characteristics.
• Chemical Biology Probes: Utilized as a building block for designing molecular probes and inhibitors to study enzyme function and biological pathways.
• Flavor and Fragrance Industry: Acts as an intermediate for synthesizing certain aroma chemicals and flavor compounds.

Basic Information

Product Name	Tetrahydro-2H-Pyran-4-Carboxylic Acid
CAS No.	5337-03-1
Molecular Formula	C6H10O3
Molecular Weight	130.14 g/mol
Synonyms	4-Carboxytetrahydropyran; Tetrahydro-4-pyrancarboxylic Acid; 4-Pyrancarboxylic Acid, Tetrahydro-; Oxane-4-carboxylic Acid; THP-4-Carboxylic Acid; Tetrahydropyran-4-carboxylic Acid; 4-Carboxyoxane
EINECS	226-259-5

Quality Control

Our Tetrahydro-2H-Pyran-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identification by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product quality and stability. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.