Description

3,17α-Bis[(Trimethylsilyl)Oxy]Estra-1,3,5(10),11-Tetrene CAS NO 5150-60-7 is a high-purity, silyl-protected derivative of an estrane-based steroid, specifically designed as a critical synthetic intermediate. This compound is valued for its role in advanced organic synthesis, where it serves as a protected precursor for the controlled introduction of functional groups at key positions on the steroid nucleus. It is primarily utilized by research institutions and pharmaceutical development teams engaged in the synthesis of novel steroid analogs, hormone derivatives, and other complex bioactive molecules.

Application

• Pharmaceutical Research & Development: A key protected intermediate in the multi-step synthesis of novel steroid-based therapeutics and hormone analogs.
• Organic Synthesis: Used in advanced laboratory-scale synthesis for the construction of complex estrane and gonane ring systems with specific stereochemistry.
• Chemical Reference Standard: Serves as a high-purity analytical standard for method development and quality control in steroid analysis.
• Academic Research: Employed in university and institutional labs for studying steroid chemistry, reaction mechanisms, and protecting group strategies.
• Process Chemistry Development: Investigated as a potential intermediate in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3,17α-Bis[(Trimethylsilyl)Oxy]Estra-1,3,5(10),11-Tetrene
CAS No.	5150-60-7
Molecular Formula	C26H42O2Si2
Molecular Weight	442.80 g/mol
Synonyms	3,17α-Bis(trimethylsiloxy)estra-1,3,5(10),11-tetraene; 3,17α-Bis(trimethylsilyloxy)estra-1,3,5(10),11-tetraene; Estra-1,3,5(10),11-tetraene-3,17α-diol, bis(trimethylsilyl) ether; 3,17α-Di-O-trimethylsilyl-δ1,3,5(10),11-estratetraene; 3,17α-Bis-O-TMS-estra-1,3,5(10),11-tetrene; 3,17α-Bis(trimethylsiloxy)-δ1,3,5(10),11-estratetraene; 3,17α-Di(trimethylsilyloxy)estra-1,3,5(10),11-tetraene
EINECS	Contact for details

Quality Control

Our 3,17α-Bis[(Trimethylsilyl)Oxy]Estra-1,3,5(10),11-Tetrene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.