Description

3-Chloro-2-Iodotoluene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chlorine and iodine substituents on the toluene backbone, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and chemical manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research for structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where its halogenated structure can be leveraged for bioactivity.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings, where the iodine atom offers superior reactivity.
• Chemical Reference Standard: Utilized in analytical laboratories as a high-purity standard for method development and quality control testing.
• Ligand and Catalyst Preparation: Employed in the synthesis of complex ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Chloro-2-Iodotoluene
CAS No.	5100-98-1
Molecular Formula	C7H6ClI
Molecular Weight	252.48 g/mol
Synonyms	1-Chloro-3-iodo-2-methylbenzene; 2-Methyl-3-chloroiodobenzene; 3-Chloro-2-iodo-1-methylbenzene; Toluene, 3-chloro-2-iodo-; 2-Iodo-3-chlorotoluene; 3-Chloro-2-iodotoluene; 2-Chloro-6-iodotoluene (numbering variant); o-Iodo-m-chlorotoluene
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Iodotoluene is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residue on Ignition	<0.1%
Related Substances (HPLC)	Total impurities <2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.