Description

4-Bromo-N,n-Bis(Trimethylsilyl)Aniline is a versatile organosilicon-protected aniline derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the dual protection of the amine group by trimethylsilyl (TMS) moieties, which enhances stability and directs regioselectivity in subsequent coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require high-purity intermediates for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing brominated aromatic amine scaffolds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the protected aniline group is a crucial structural element.
• Material Science & OLED Development: Serves as a monomer or intermediate in the production of organic semiconductors, charge-transport materials, and light-emitting layers for electronic devices.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Buchwald-Hartwig, and Negishi couplings, leveraging the bromo substituent.
• Ligand & Catalyst Preparation: Utilized in the synthesis of specialized nitrogen-containing ligands for homogeneous catalysis.
• Organic Synthesis Protecting Group: The bis(trimethylsilyl)amine group acts as a protective strategy for anilines, allowing for selective functionalization at other sites on the aromatic ring.

Basic Information

Product Name	4-Bromo-N,n-Bis(Trimethylsilyl)Aniline
CAS No.	5089-33-8
Molecular Formula	C12H22BrNSi2
Molecular Weight	316.39 g/mol
Synonyms	4-Bromo-N,N-bis(trimethylsilyl)benzenamine; N,N-Bis(trimethylsilyl)-4-bromoaniline; 4-Bromo-N,N-bis(trimethylsilyl)aniline; Benzenamine, 4-bromo-N,N-bis(trimethylsilyl)-; 4-Bromophenylbis(trimethylsilyl)amine; p-Bromo-N,N-bis(trimethylsilyl)aniline; TMS-protected 4-bromoaniline
EINECS	Contact for details

Quality Control

Our 4-Bromo-N,n-Bis(Trimethylsilyl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We are committed to meeting the stringent requirements of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.