Description

12Alpha-Hydroxyrotenone is a hydroxylated derivative of the natural isoflavonoid rotenone, a compound of significant interest in biochemical research. This specific structural analog is primarily valued for its utility as a key intermediate or reference standard in the study of botanical insecticides and mitochondrial complex I inhibitors. It serves critical roles for researchers and developers in agrochemical R&D, phytochemistry, and biochemical pharmacology, enabling the investigation of structure-activity relationships and metabolic pathways.

Application

• Agrochemical Research & Development: Used as a biochemical tool and synthetic intermediate in the study of novel, naturally-derived insecticide candidates.
• Phytochemical Reference Standard: Serves as a high-purity analytical standard for the identification and quantification of rotenone derivatives in plant extracts and botanical products.
• Biochemical Studies: Employed in research focused on mitochondrial respiration and electron transport chain inhibition, specifically targeting complex I (NADH:ubiquinone oxidoreductase).
• Metabolism and Toxicology Research: Acts as a metabolite analog in studies investigating the biotransformation, environmental fate, and toxicological profile of rotenone-based compounds.
• Organic Synthesis: Functions as a specialized building block for the chemical synthesis of more complex rotenoids and related isoflavonoids for structure-activity relationship (SAR) studies.

Basic Information

Product Name	12Alpha-Hydroxyrotenone
CAS No.	545-76-6
Molecular Formula	C23H22O7
Molecular Weight	410.42 g/mol
Synonyms	12α-Hydroxyrotenone; 12-Hydroxyrotenone; (6aS,12aS,12bS)-12-Hydroxy-6a,12a-dihydro-2H-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one; Rotenone, 12-hydroxy-; 12-Hydroxy-6a,12a-dihydro-2H-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
EINECS	Contact for details

Quality Control

Our 12Alpha-Hydroxyrotenone is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods (IR, NMR) for structural confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) documenting identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize oxidation and degradation. Keep the container tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.