Description

Deguelin is a naturally occurring rotenoid compound, a member of the flavonoid family, identified by CAS number 522-17-8. This bioactive molecule is of significant interest for its potent biological activities, particularly as a selective inhibitor of certain cellular pathways. It serves as a critical research-grade biochemical for scientists in pharmaceutical discovery, agrochemical development, and life sciences research, enabling the study of cellular mechanisms and potential therapeutic or agrochemical applications.

Application

• Pharmaceutical Research & Drug Discovery: Used as a reference standard and active investigational compound in studies targeting cancer, metabolic disorders, and neurological conditions.
• Biochemical Pathway Analysis: Serves as a specific tool compound in molecular biology to study and inhibit key signaling pathways, such as the PI3K/Akt/mTOR axis.
• Agrochemical Research: Investigated for its potential as a natural insecticide or pesticide lead due to its rotenoid structure and biological activity.
• Academic & Institutional Research: Employed in universities and research institutes for fundamental studies in cell biology, pharmacology, and toxicology.
• Reference Standard Manufacturing: Supplied to laboratories for use as a high-purity calibration standard in analytical methods like HPLC and LC-MS.
• Cosmeceutical Ingredient Research: Explored in R&D for potential applications in skincare formulations due to its bioactive properties.

Basic Information

Product Name	Deguelin
CAS No.	522-17-8
Molecular Formula	C23H22O6
Molecular Weight	394.42 g/mol
Synonyms	(-)-Deguelin; 13,13a-Didehydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one; Rotenone, dihydro-; NSC 146051; Tubaol; (7aS,13aR)-13,13a-Didehydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
EINECS	208-324-2

Quality Control

Our Deguelin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with various research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to prevent contamination.

Specification

Item	Specification
Appearance	Light yellow to yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Loss on Drying	≤ 2.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.