Description

12Alpha-Hydroxyrotenone is a naturally occurring isoflavonoid derivative, structurally related to the well-known botanical insecticide rotenone. This compound is of significant interest in research and development for its unique biological activity profile. It serves as a valuable reference standard and key intermediate for scientists in agrochemical, pharmaceutical, and biochemical sectors exploring novel bioactive molecules.

Application

• Pharmaceutical Research Intermediate: Serves as a crucial building block in the synthesis and development of novel therapeutic agents.
• Agrochemical Reference Standard: Used as a high-purity analytical standard for quality control and residue analysis in pesticide formulations and environmental testing.
• Biochemical Research: Employed in studies investigating mitochondrial complex I inhibition and its effects on cellular metabolism.
• Natural Product Chemistry: Acts as a model compound for the synthesis and structural modification of complex rotenoid derivatives.
• Academic & Institutional Research: Utilized in universities and research institutes for pharmacological and toxicological studies.

Basic Information

Product Name	12Alpha-Hydroxyrotenone
CAS No.	509-96-6
Molecular Formula	C23H22O7
Molecular Weight	410.42 g/mol
Synonyms	12α-Hydroxyrotenone; 12-Hydroxyrotenone; NSC 168101; 6aβ,12aβ-12-Hydroxyrotenone; (6aR,12aS)-12-Hydroxyrotenone; Deguelin, 12-hydroxy-; 12-Hydroxy-13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(13aH)-one
EINECS	Contact for details

Quality Control

Every batch of 12Alpha-Hydroxyrotenone is produced and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the exacting requirements of research and development. A Certificate of Analysis (COA) detailing specifications such as assay purity (by HPLC), identification (by IR/UV), and related substance profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.