Description

(S)-(-)-Tetrahydrofuran-2-Carboxylic Acid Amide is a high-purity, single-enantiomer chiral building block of significant importance in asymmetric synthesis. Its value lies in its utility as a key intermediate for constructing complex molecules with defined stereochemistry, which is critical for biological activity. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries developing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing specialized ligands used in enantioselective catalytic reactions.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and pesticides where specific stereochemistry enhances efficacy and reduces environmental impact.
• Fine Chemical Building Block: Employed in the custom synthesis of complex, high-value specialty chemicals for research and industrial applications.
• Academic & Process Chemistry Research: A valuable tool for methodological development in organic synthesis and scale-up process optimization studies.

Basic Information

Product Name	(S)-(-)-Tetrahydrofuran-2-Carboxylic Acid Amide
CAS No.	498573-81-2
Molecular Formula	C5H9NO2
Molecular Weight	115.13 g/mol
Synonyms	(S)-2-Carbamoyltetrahydrofuran; (S)-Tetrahydro-2-furancarboxamide; (S)-(-)-2-Tetrahydrofurancarboxamide; L-Proline amide, 2,5-dihydro-; (2S)-Oxolane-2-carboxamide; (S)-α-(Aminocarbonyl)tetrahydrofuran; (S)-THF-2-Carboxamide
EINECS	Contact for details

Quality Control

Our (S)-(-)-Tetrahydrofuran-2-Carboxylic Acid Amide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.