Description

2-Chloro-4-Fluorophenylzinc Iodide is a versatile organozinc reagent, a key building block for the formation of carbon-carbon bonds in advanced organic synthesis. Its value lies in its ability to facilitate efficient cross-coupling reactions, such as Negishi coupling, enabling the precise construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity intermediates for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for constructing biaryl and heterobiaryl scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Product Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring specific halogenated phenyl groups.
• Material Science Research: Serves as a precursor for creating functionalized organic molecules used in organic light-emitting diodes (OLEDs) and liquid crystals.
• Negishi Cross-Coupling Reactions: Acts as the organozinc component for coupling with various organic electrophiles (aryl halides, vinyl halides) in the presence of palladium catalysts.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects and library production.
• Academic & Industrial R&D: A valuable tool for methodological development in synthetic organic chemistry and catalysis studies.

Basic Information

Product Name	2-Chloro-4-Fluorophenylzinc Iodide
CAS No.	497923-83-8
Molecular Formula	C6H3ClFZnI
Molecular Weight	312.34 g/mol
Synonyms	(2-Chloro-4-fluorophenyl)zinc iodide; Zinc, (2-chloro-4-fluorophenyl)iodo-; 2-Chloro-4-fluoroiodobenzene zinc reagent; (2-Chloro-4-fluorophenyl)zinc iodide solution; 2-Cl-4-F-C6H3ZnI
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluorophenylzinc Iodide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and concentration (typically supplied as a solution in THF or other ethereal solvents). A comprehensive Certificate of Analysis (COA) detailing assay (by titration), solvent content, and impurity profile is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. Due to its moisture-sensitive and pyrophoric nature, the reagent must be handled under anhydrous conditions using standard Schlenk line or glovebox techniques. Keep away from heat, sparks, open flames, and strong oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (on an anhydrous basis)
Solvent	Specified (e.g., Tetrahydrofuran)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.