Description

n-Benzyl-4-(1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)-n-Methylbenzenesulfonamide CAS NO 497089-99-3 is a high-purity, specialized organic compound featuring a unique sulfonamide and phthalimide hybrid structure. This molecular architecture makes it a valuable advanced pharmaceutical intermediate for the research and development of novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly those targeting enzymes or receptors where the sulfonamide and imide functionalities are critical for bioactivity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities with improved efficacy and safety profiles.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of various proteases, given the sulfonamide group's ability to act as a zinc-binding motif or hydrogen bond acceptor.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study biological pathways and protein functions within academic and industrial research settings.
• Custom Synthesis & Scale-Up: Employed by contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects, from milligram-scale research to kilogram-scale pilot production.
• Library Synthesis for High-Throughput Screening: Acts as a versatile intermediate for generating diverse compound libraries to screen against novel biological targets in drug discovery.

Basic Information

Product Name	n-Benzyl-4-(1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)-n-Methylbenzenesulfonamide
CAS No.	497089-99-3
Molecular Formula	C22H18N2O4S
Molecular Weight	406.46 g/mol
Synonyms	N-Benzyl-4-(1,3-dioxoisoindolin-2-yl)-N-methylbenzenesulfonamide; 2-[4-[(Benzylmethylamino)sulfonyl]phenyl]isoindoline-1,3-dione; N-Methyl-N-benzyl-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzenesulfonamide; Benzenesulfonamide, N-benzyl-4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-N-methyl-; 497089-99-3; BDBM50164957; AOB31117; ZINC000003869756
EINECS	Contact for details

Quality Control

Our n-Benzyl-4-(1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)-n-Methylbenzenesulfonamide is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent quality for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.