Description

Proline, 3-Methyl-, Ethyl Ester (9Ci) is a high-purity, non-natural amino acid derivative, specifically an ethyl ester of 3-methylproline. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and industrial R&D departments focused on medicinal chemistry, peptide mimetics, and the synthesis of complex natural products.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetics & Drug Design: Used to introduce constrained proline analogs into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective synthesis for constructing complex molecules with defined stereochemistry.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, or plant growth regulators that incorporate modified amino acid structures.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to probe the function of proline-specific enzymes.
• Fine Chemical Synthesis: A valuable intermediate for custom synthesis and contract manufacturing of specialty chemicals for various high-value applications.

Basic Information

Product Name	Proline, 3-Methyl-, Ethyl Ester (9Ci)
CAS No.	497066-73-6
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	Ethyl 3-Methylprolinate; 3-Methylproline Ethyl Ester; L-Proline, 3-methyl-, ethyl ester (9CI); Ethyl 3-methylpyrrolidine-2-carboxylate; 2-Pyrrolidinecarboxylic acid, 3-methyl-, ethyl ester; (2S,3S)-3-Methylproline ethyl ester; (2S,3R)-3-Methylproline ethyl ester
EINECS	Contact for details

Quality Control

Our Proline, 3-Methyl-, Ethyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) documenting identity, purity (typically ≥95% by HPLC), and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (specify isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.