Description

trans-2,2-Dimethyl-3-phenylcyclopropane-1-carboxylic acid is a high-purity, synthetically valuable cyclopropane derivative. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, prized for its rigid, three-membered ring structure that imparts unique steric and electronic properties to target molecules. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, including protease inhibitors, CNS-active compounds, and other biologically active molecules.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the cyclopropane moiety can enhance biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for creating polymers with specific thermal or mechanical properties.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fragrance and flavor compounds.
• Academic & Research: A valuable reagent for methodological studies in organic chemistry, particularly in cyclopropanation and ring transformation reactions.

Basic Information

Product Name	trans-2,2-Dimethyl-3-phenylcyclopropane-1-carboxylic Acid
CAS No.	494846-26-3
Molecular Formula	C₁₂H₁₄O₂
Molecular Weight	190.24 g/mol
Synonyms	trans-2,2-Dimethyl-3-phenylcyclopropanecarboxylic acid; (1R,3S)-2,2-Dimethyl-3-phenylcyclopropane-1-carboxylic acid (enantiomer); 2,2-Dimethyl-3-phenylcyclopropanecarboxylic acid; Phenylcyclopropanecarboxylic acid derivative; Cyclopropane-1-carboxylic acid, 2,2-dimethyl-3-phenyl-, trans-; Aromatic cyclopropane carboxylate
EINECS	Contact for details

Quality Control

Our trans-2,2-Dimethyl-3-phenylcyclopropane-1-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.