Description

1,1-Bis[(2S,3S,4S,5S)-2,5-Dimethyl-3,4-o-Isopropylidene-3,4-Dihydroxyphospholanyl]Ferrocene is a highly specialized chiral phosphine ligand, distinguished by its ferrocene backbone and stereochemically defined phospholane groups. This compound is critical for enabling highly enantioselective transformations in asymmetric catalysis, offering superior control over stereochemistry. It is primarily sought after by research institutions and pharmaceutical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and fine chemical intermediates.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acids and amines.
• Catalyst component in the enantioselective synthesis of pharmaceutical intermediates, including β-blockers and other chiral drugs.
• Use in asymmetric C-C bond-forming reactions, such as allylic alkylation and cross-coupling, for advanced organic synthesis.
• Key reagent in academic and industrial research for developing new catalytic methodologies in stereochemistry.
• Potential application in the synthesis of agrochemicals requiring high enantiopurity.
• Component in catalyst screening kits for high-throughput experimentation (HTE) in drug discovery.

Basic Information

Product Name	1,1-Bis[(2S,3S,4S,5S)-2,5-Dimethyl-3,4-o-Isopropylidene-3,4-Dihydroxyphospholanyl]Ferrocene
CAS No.	488760-58-3
Molecular Formula	C28H40FeO4P2
Molecular Weight	558.38 g/mol
Synonyms	(S,S)-1,1'-Bis(2,5-dimethylphospholano)ferrocene; Josiphos SL-J009-1; (S,S)-J009-1; (S,S)-1,1'-Bis[(2S,5S)-2,5-dimethylphospholano]ferrocene; (S,S)-1,1'-Bis(2,5-dimethylphospholan-1-yl)ferrocene; (S,S)-Dioxy-Josiphos ligand; Chiral Josiphos-type ligand; Ferrocenyl bisphospholane ligand
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized by advanced analytical techniques, including NMR, HPLC, and chiral analysis, to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and hygroscopic (moisture-sensitive), it is recommended to store the material under an inert gas (argon or nitrogen) in a cool (2-8°C), dry environment. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.