Description

4-Bromo-2,5-Difluorophenol is a halogenated fluorophenol derivative that serves as a versatile and high-value synthetic intermediate in advanced organic chemistry. Its precise molecular architecture, featuring both bromine and fluorine substituents on the phenolic ring, makes it a critical building block for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to develop active ingredients, as well as in materials science for creating specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the difluorophenol moiety can enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorine-containing liquid crystal compounds used in advanced display technologies.
• Polymer Chemistry: Incorporated as a monomer or modifier in the production of high-performance, halogenated polymers with specific thermal or chemical resistance.
• Organic Electronic Materials: Utilized in the research and development of organic semiconductors and electro-optical materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form complex biaryl structures.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry in both academic and industrial R&D settings.

Basic Information

Product Name	4-Bromo-2,5-Difluorophenol
CAS No.	486424-36-6
Molecular Formula	C6H3BrF2O
Molecular Weight	208.99 g/mol
Synonyms	4-Bromo-2,5-difluorophenol; 2,5-Difluoro-4-bromophenol; Phenol, 4-bromo-2,5-difluoro-; 4-Bromo-2,5-difluoro-1-hydroxybenzene; 1-Bromo-4-fluoro-2,5-difluorophenol (incorrect but common misordering); 4-Br-2,5-F2-PhOH (abbreviation); BDFP (abbreviation)
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,5-Difluorophenol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data to support your quality and regulatory requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request. Our quality commitment aligns with cGMP standards where applicable for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its phenolic and light-sensitive nature, prolonged exposure to light or elevated temperatures should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.