Description

3-((2S,5S)-5-(3-((tert-Butyldiphenylsilyl)Oxy)Propyl)-3-Methylenetetrahydrofuran-2-Yl)Propan-1-Ol is a high-value, chiral synthetic intermediate featuring a protected hydroxyl group and a methylenetetrahydrofuran core. This compound is critical for researchers and manufacturers requiring precise stereochemistry and functional group manipulation in complex organic syntheses. It is primarily sought after by the pharmaceutical and advanced fine chemical industries for the development of novel active pharmaceutical ingredients (APIs) and other sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of potential drug candidates, particularly in medicinal chemistry research.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex molecules with defined three-dimensional structures.
• Natural Product Synthesis: Serves as a precursor in the total synthesis of complex natural products containing furan or tetrahydrofuran motifs.
• Protecting Group Chemistry: The tert-butyldiphenylsilyl (TBDPS) group allows for selective protection and deprotection strategies during synthetic sequences.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale for new chemical entities.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological pathways and target engagement.

Basic Information

Item	Details
Product Name	3-((2S,5S)-5-(3-((tert-Butyldiphenylsilyl)Oxy)Propyl)-3-Methylenetetrahydrofuran-2-Yl)Propan-1-Ol
CAS No.	481048-21-9
Molecular Formula	C27H38O3Si
Molecular Weight	438.68 g/mol
Synonyms	(2S,5S)-5-[3-[(1,1-Dimethylethyl)diphenylsilyl]oxypropyl]-3-methylenetetrahydro-2-furanpropanol; (2S,5S)-5-(3-((tert-Butyldiphenylsilyl)oxy)propyl)-3-methylenetetrahydrofuran-2-propan-1-ol; TBDPS-protected chiral furan alcohol; (2S,5S)-TBDPS-O-(CH2)3-tetrahydrofuran propanol derivative
EINECS	Contact for details

Quality Control

Our 3-((2S,5S)-5-(3-((tert-Butyldiphenylsilyl)Oxy)Propyl)-3-Methylenetetrahydrofuran-2-Yl)Propan-1-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.