Description

3-(Trifluoromethyl)Benzylzinc Chloride is a versatile organozinc reagent, a key building block in modern synthetic chemistry. Its value lies in enabling efficient carbon-carbon bond formation, specifically through Negishi cross-coupling reactions, which are critical for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require a reliable, high-purity reagent for introducing the 3-(trifluoromethyl)benzyl moiety.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for constructing active pharmaceutical ingredients (APIs), particularly those containing the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides where the benzyl and trifluoromethyl groups contribute to biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for specialized ligands and organometallic catalysts used in asymmetric synthesis and polymerization processes.
• Advanced Material Research: Employed in the development of organic electronic materials, liquid crystals, and specialty polymers with tailored properties.
• Negishi Cross-Coupling Reactions: Primarily used to couple the 3-(trifluoromethyl)benzyl group with various aryl, vinyl, or alkynyl halides under palladium or nickel catalysis.
• Custom Fine Chemical Manufacturing: A key building block for contract research and manufacturing organizations (CROs/CMOs) producing high-value, custom-synthesized compounds.

Basic Information

Item	Detail
Product Name	3-(Trifluoromethyl)Benzylzinc Chloride
CAS No.	480438-42-4
Molecular Formula	C8H6ClF3Zn
Molecular Weight	259.96 g/mol
Synonyms	(3-(Trifluoromethyl)benzyl)zinc chloride; Zinc, chloromethyl[3-(trifluoromethyl)phenyl]-; 3-(Trifluoromethyl)benzylzinc chloride solution; α-(Trifluoromethyl)benzylzinc chloride; (3-Trifluoromethylbenzyl)zinc chloride; (m-Trifluoromethylbenzyl)zinc chloride; Benzylzinc chloride, 3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)Benzylzinc Chloride is manufactured under stringent quality systems. Each batch undergoes rigorous analytical testing, including titration for zinc content and GC/HPLC analysis for purity and identity, to ensure consistency and reliability for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and solution concentration is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is moisture-sensitive (hygroscopic) and easily oxidized; ensure containers are sealed immediately after use to exclude air and moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in Tetrahydrofuran (Typical)
Assay (Titration)	≥ 95%
Purity (GC/HPLC)	≥ 90% (Organozinc species)
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.