Description

Methanesulfonic Acid, Trifluoro-, 1H-Pyrrolo[2,3-B]Pyridin-4-Yl Ester (9Ci) is a specialized fluorinated sulfonate ester building block of significant interest in advanced organic synthesis. Its core value lies in its role as a key intermediate for constructing complex heterocyclic scaffolds, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily needed by research chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially kinase inhibitors and other targeted therapeutics. The CAS number for this compound is 479552-94-8.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex heterocyclic compounds, particularly for the development of kinase inhibitors and other small-molecule drug candidates.
• Agrochemical Research: Used in the discovery and development of novel pesticides and herbicides, leveraging its unique fluorinated pyrrolopyridine structure.
• Material Science: Serves as a precursor for functionalized molecules used in advanced materials, such as organic semiconductors or liquid crystals.
• Chemical Biology: Employed as a probe or labeling reagent in biochemical research due to its reactive ester group and fluorinated tag.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of high-value fine chemicals.

Basic Information

Product Name	Methanesulfonic Acid, Trifluoro-, 1H-Pyrrolo[2,3-B]Pyridin-4-Yl Ester (9Ci)
CAS No.	479552-94-8
Molecular Formula	C9H5F3N2O2S
Molecular Weight	262.21 g/mol
Synonyms	4-(Trifluoromethanesulfonyloxy)-7-azaindole; 1H-Pyrrolo[2,3-b]pyridin-4-yl trifluoromethanesulfonate; 7-Azaindol-4-yl Triflate; 4-Triflyloxy-7-azaindole; 4-OTf-7-Azaindole; Trifluoromethanesulfonic Acid 1H-Pyrrolo[2,3-b]pyridin-4-yl Ester; 4-(Trifluoromethylsulfonyloxy)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. For this high-purity synthetic intermediate, quality is assured through multiple analytical techniques. Certificates of Analysis (COA) are provided with each batch, detailing key parameters such as purity, identity, and impurity profile. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.