Description

1-Phenyl-2,5,8,11-Tetraoxatridecan-13-Yl Methanesulfonate is a specialized organic compound featuring a phenyl group linked to a polyethylene glycol-like chain terminated with a methanesulfonate ester. This unique structure makes it a valuable chemical intermediate and functionalization reagent for introducing hydrophilic, solubilizing polyether chains onto target molecules. It is primarily utilized in advanced research and development, particularly in the pharmaceutical and materials science sectors, where precise molecular modification is required for creating novel polymers, prodrugs, or surface-active agents.

Application

• Pharmaceutical Intermediate: Used in the synthesis of prodrugs and drug conjugates to enhance solubility and bioavailability of active pharmaceutical ingredients (APIs).
• Polymer Chemistry: Serves as a functional monomer or chain-transfer agent for the synthesis of specialized polyethers and block copolymers with tailored properties.
• Surface Modification: Employed to functionalize nanoparticles, silica, or other solid supports with poly(ethylene glycol) (PEG) chains to improve biocompatibility and dispersion.
• Bioconjugation: Acts as a linker reagent for attaching molecules (e.g., dyes, targeting agents) to proteins, peptides, or other biomolecules via the reactive methanesulfonate group.
• Ligand Synthesis: Useful in creating chelating agents and ligands for catalysis or metal ion sequestration.
• Material Science Research: A key building block in developing non-ionic surfactants, hydrogels, and other advanced functional materials.

Basic Information

Product Name	1-Phenyl-2,5,8,11-Tetraoxatridecan-13-Yl Methanesulfonate
CAS No.	477781-69-4
Molecular Formula	C17H28O7S
Molecular Weight	376.47 g/mol
Synonyms	1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate; Methanesulfonic acid 1-phenyl-2,5,8,11-tetraoxatridecan-13-yl ester; PEG4-Phenyl Mesylate; 2-[2-[2-[2-(2-Phenoxyethoxy)ethoxy]ethoxy]ethoxy]ethyl methanesulfonate; Tetraethylene glycol phenyl ether methanesulfonate; 4,7,10,13-Tetraoxa-1-phenylhexadecan-16-yl methanesulfonate; Phenyl-PEG4-mesylate
EINECS	Contact for details

Quality Control

Our production of 1-Phenyl-2,5,8,11-Tetraoxatridecan-13-Yl Methanesulfonate adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.