Description

m-Peg7-Ms is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a methoxy group at one terminus and a reactive mesylate (Ms) group at the other. This molecular architecture is critical for creating stable, hydrophilic linkers in bioconjugation and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for PEGylating peptides, proteins, and small molecule APIs to enhance solubility, stability, and pharmacokinetic profiles.

Application

• Pharmaceutical PEGylation: Conjugation linker for modifying therapeutic proteins, peptides, and oligonucleotides to improve circulatory half-life and reduce immunogenicity.
• Bioconjugation Reagent: Used to attach drugs, dyes, or other functional molecules to targeting ligands like antibodies or peptides.
• ADC (Antibody-Drug Conjugate) Development: Serves as a hydrophilic spacer in linker-payload constructs to modulate hydrophilicity and aggregation.
• Polymer Chemistry: A versatile building block for synthesizing functionalized PEG-based block copolymers, hydrogels, and drug delivery systems.
• Surface Modification: Employed to create hydrophilic, non-fouling coatings on nanoparticles, medical devices, and diagnostic sensors.
• Cross-linking Agent: Used in the preparation of cross-linked biomaterials and matrices for controlled release applications.

Basic Information

Product Name	m-Peg7-Ms
CAS No.	477775-57-8
Molecular Formula	C17H36O9S
Molecular Weight	416.53 g/mol
Synonyms	mPEG7-Ms; Methoxy-PEG7-mesylate; α-Methoxy-ω-mesyl-polyethylene glycol (n=7); 2,5,8,11,14,17,20-Heptaoxadocosan-22-yl methanesulfonate; mPEG7-OMs; Monomethoxy heptaethylene glycol mesylate; PEG7 monomethyl ether mesylate; Heptaethylene glycol monomethyl ether methanesulfonate
EINECS	Contact for details

Quality Control

Our m-Peg7-Ms is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and critical impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 90.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.