Description

6-Methoxy-1-Methyl-1,3A,4,9B-Tetrahydro-3H-Chromeno[4,3-C]Isoxazole is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused chromeno-isoxazole heterocyclic structure. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and anti-inflammatory drug discovery programs. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers seeking reliable, high-quality building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• CNS Drug Development: Explored in the synthesis of potential therapeutics for disorders such as anxiety, depression, and neurodegenerative diseases due to its privileged heterocyclic structure.
• Contract Synthesis: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and process development projects.
• Academic Research: Utilized in university and institutional laboratories for fundamental research in organic synthesis and heterocyclic chemistry.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) in early-stage drug discovery.

Basic Information

Product Name	6-Methoxy-1-Methyl-1,3A,4,9B-Tetrahydro-3H-Chromeno[4,3-C]Isoxazole
CAS No.	477713-63-6
Molecular Formula	C₁₂H₁₃NO₃
Molecular Weight	219.24 g/mol
Synonyms	6-Methoxy-1-methyl-1,3a,4,9b-tetrahydro-3H-chromeno[4,3-c]isoxazole; Chromeno[4,3-c]isoxazole, 6-methoxy-1-methyl-1,3a,4,9b-tetrahydro-3H-; 1,3a,4,9b-Tetrahydro-6-methoxy-1-methyl-3H-chromeno[4,3-c]isoxazole; 6-Methoxy-1-methyl-1,3a,4,9b-tetrahydrochromeno[4,3-c]isoxazole; 3H-Chromeno[4,3-c]isoxazole, 1,3a,4,9b-tetrahydro-6-methoxy-1-methyl-
EINECS	Contact for details

Quality Control

Our 6-Methoxy-1-Methyl-1,3A,4,9B-Tetrahydro-3H-Chromeno[4,3-C]Isoxazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.