Description

D-4'-Tetrahydropyranylglycine is a specialized, non-proteinogenic amino acid derivative featuring a tetrahydropyranyl protecting group. This compound is of significant value in advanced organic synthesis and pharmaceutical research, serving as a crucial chiral building block for the development of novel peptide-based therapeutics and bioactive molecules. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers focused on peptide synthesis, medicinal chemistry, and the production of high-value intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex peptide drugs and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used to introduce the glycine moiety with an orthogonal protecting group in solid-phase and solution-phase peptide synthesis.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the design of new drug candidates targeting various diseases.
• Bioconjugation: Acts as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Utilized in the synthesis of labeled amino acids and probes for studying biological processes.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to construct stereogenic centers.

Basic Information

Product Name	D-4'-Tetrahydropyranylglycine
CAS No.	475649-32-2
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	D-THP-Gly-OH; (R)-2-((Tetrahydro-2H-pyran-4-yl)oxy)acetic Acid; D-2-(Tetrahydro-2H-pyran-4-yloxy)acetic Acid; Glycine, N-[(3R)-tetrahydro-2H-pyran-4-yl]-; (R)-N-(Tetrahydro-2H-pyran-4-yl)glycine; D-α-(Tetrahydro-2H-pyran-4-yl)glycine; D-THP-Glycine; Boc-D-THP-Gly-OH (when protected)
EINECS	Contact for details

Quality Control

Our D-4'-Tetrahydropyranylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (typically ≥98%), and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.