Description

4-Isothiazolecarboxylic Acid is a versatile heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the reactive carboxylic acid group attached to the isothiazole ring, enabling its use as a key precursor for pharmaceuticals, agrochemicals, and functional materials. This compound is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical and agrochemical industries for constructing novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly those targeting infectious diseases or central nervous system disorders.
• Agrochemical Synthesis: Used in the research and production of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the isothiazole moiety.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of polymers and organic electronic materials with specific optoelectronic properties.
• Chemical Biology Probes: Utilized to synthesize molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects requiring functionalized isothiazole derivatives.

Basic Information

Product Name	4-Isothiazolecarboxylic Acid
CAS No.	475112-25-5
Molecular Formula	C4H3NO2S
Molecular Weight	129.14 g/mol
Synonyms	1,2-Thiazole-4-carboxylic acid; Isothiazole-4-carboxylic acid; 4-Carboxyisothiazole; 1,2-Thiazole-4-carboxylic acid (9CI); 4-Isothiazolecarboxylic acid (6CI,7CI); 4-Isothiazolecarboxylic acid, 1,2-Thiazole-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Isothiazolecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.