Description

(S)-2-Amino-4-(tert-Butyldimethylsilyloxy)Butanoic Acid is a high-purity, chiral amino acid derivative featuring a tert-butyldimethylsilyl (TBDMS) protecting group on the side-chain hydroxyl. This compound is a critical building block in advanced organic synthesis, particularly for the preparation of complex peptides and pharmaceutical intermediates where precise stereochemistry is paramount. It is essential for researchers and manufacturers in pharmaceutical development, peptide chemistry, and proteomics who require reliable, high-quality chiral synthons.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate serine or threonine analogs with a protected side-chain.
• Protease Inhibitor Development: Serves as a core structural component in designing enzyme inhibitors for therapeutic applications.
• Bioconjugation & Labeling: Facilitates the site-specific modification of peptides and proteins for diagnostic and research purposes.
• Chemical Biology Probes: Employed in the creation of molecular probes to study biological pathways and protein function.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective catalytic reactions.

Basic Information

Product Name	(S)-2-Amino-4-(tert-Butyldimethylsilyloxy)Butanoic Acid
CAS No.	474023-97-7
Molecular Formula	C10H23NO3Si
Molecular Weight	233.39 g/mol
Synonyms	(S)-2-Amino-4-((tert-butyldimethylsilyl)oxy)butanoic acid; O-(tert-Butyldimethylsilyl)-L-serine; L-Serine, O-[1,1-dimethylethyl)dimethylsilyl]-; (S)-2-Amino-4-(tert-butyldimethylsiloxy)butyric acid; TBDMS-L-serine; (S)-2-Amino-4-[(tert-butyldimethylsilyl)oxy]butanoic acid; 474023-97-7; O-TBDMS-L-serine
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-4-(tert-Butyldimethylsilyloxy)Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric excess, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.