Description

3-Hydroxymethyl-Morpholine-4-Carboxylic Acid tert-Butyl Ester is a high-value, protected morpholine derivative that serves as a critical building block in advanced organic synthesis. Its primary commercial value lies in its role as a versatile intermediate for constructing complex pharmaceutical molecules and fine chemicals. This compound is particularly sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, particularly those containing morpholine or piperazine scaffolds.
• API Development: Used in research and process chemistry for constructing the core structures of potential therapeutic agents.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Preparation: Utilized for creating chiral auxiliaries, ligands for asymmetric catalysis, and organocatalysts.
• Peptidomimetics & Bioactive Molecules: The morpholine ring and protected carboxylic acid group make it valuable for designing peptide analogs and other bioactive compounds.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Hydroxymethyl-Morpholine-4-Carboxylic Acid tert-Butyl Ester
CAS No.	473923-56-7
Molecular Formula	C10H19NO4
Molecular Weight	217.26 g/mol
Synonyms	tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate; 4-(tert-Butoxycarbonyl)-3-(hydroxymethyl)morpholine; 3-(Hydroxymethyl)morpholine-4-carboxylic acid tert-butyl ester; N-Boc-3-hydroxymethylmorpholine; Morpholine-4-carboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester; Boc-3-hydroxymethylmorpholine
EINECS	Contact for details

Quality Control

Our 3-Hydroxymethyl-Morpholine-4-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where required and can provide material meeting specific customer protocols for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.