Description

2H-Pyran-4-Carbonitrile, Tetrahydro-4-[4-(Trifluoromethoxy)Phenyl]- is a specialized organic compound featuring a tetrahydro-2H-pyran core substituted with a nitrile group and a trifluoromethoxy phenyl moiety. This structure matters as it serves as a key synthetic intermediate for the development of advanced pharmaceutical and agrochemical products, where the trifluoromethoxy group is prized for its ability to modulate lipophilicity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethoxy group.
• Material Science Precursor: Serves as a monomer or functional additive in the creation of specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry for the design of novel ligands and catalysts used in asymmetric synthesis.
• Fluorine Chemistry Studies: Acts as a model compound in research focused on the synthesis and reactivity of fluorinated organic molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2H-Pyran-4-Carbonitrile, Tetrahydro-4-[4-(Trifluoromethoxy)Phenyl]-
CAS No.	473706-16-0
Molecular Formula	C13H12F3NO2
Molecular Weight	271.24 g/mol
Synonyms	4-[4-(Trifluoromethoxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile; Tetrahydro-4-[4-(trifluoromethoxy)phenyl]-2H-pyran-4-carbonitrile; 4-(4-(Trifluoromethoxy)phenyl)tetrahydro-2H-pyran-4-carbonitrile; 2H-Pyran-4-carbonitrile, tetrahydro-4-[4-(trifluoromethoxy)phenyl]-; 473706-16-0; 4-(4-Trifluoromethoxyphenyl)tetrahydropyran-4-carbonitrile
EINECS	Contact for details

Quality Control

Our high-purity 2H-Pyran-4-Carbonitrile, Tetrahydro-4-[4-(Trifluoromethoxy)Phenyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.