Description

4-(4-Fluoro-Phenyl)-Tetrahydro-Pyran-4-Carboxylic Acid CAS NO 473706-11-5 is a high-value fluorinated heterocyclic building block, a carboxylic acid derivative of a tetrahydro-2H-pyran ring substituted with a fluorophenyl group. This compound is critical for its role as a versatile synthetic intermediate in advanced pharmaceutical and agrochemical research and development. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where the fluorine atom and the carboxylic acid moiety impart desirable biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or metal-organic frameworks (MOFs) in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of specialty monomers for advanced polymers with specific thermal or optical properties.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	4-(4-Fluoro-Phenyl)-Tetrahydro-Pyran-4-Carboxylic Acid
CAS No.	473706-11-5
Molecular Formula	C12H13FO3
Molecular Weight	224.23 g/mol
Synonyms	4-(4-Fluorophenyl)tetrahydro-2H-pyran-4-carboxylic acid; 4-(4-Fluorophenyl)oxane-4-carboxylic acid; 4-Carboxy-4-(4-fluorophenyl)tetrahydropyran; 4-(4-Fluorophenyl)-4-carboxytetrahydropyran; 4-(p-Fluorophenyl)tetrahydropyran-4-carboxylic acid; 4-(4-Fluorophenyl)tetrahydro-2H-pyran-4-carboxylic Acid; 4-Fluorophenyl-tetrahydropyran-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-(4-Fluoro-Phenyl)-Tetrahydro-Pyran-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.