Description

4-(4-Fluorophenyl)Tetrahydro-2H-Pyran-4-Carbonitrile is a high-purity fluorinated heterocyclic nitrile building block. This compound is valued for its unique molecular scaffold, which combines a fluorinated aromatic ring with a tetrahydropyran moiety and a reactive nitrile group, making it a versatile intermediate in advanced synthetic chemistry. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammatory diseases, and metabolic conditions.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atom and heterocyclic structure can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functional polymers, liquid crystals, or organic electronic materials due to its rigid, fluorinated structure.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-(4-Fluorophenyl)Tetrahydro-2H-Pyran-4-Carbonitrile
CAS No.	473706-10-4
Molecular Formula	C₁₂H₁₂FNO
Molecular Weight	205.23 g/mol
Synonyms	4-(4-Fluorophenyl)tetrahydro-2H-pyran-4-carbonitrile; 4-Cyano-4-(4-fluorophenyl)tetrahydro-2H-pyran; Tetrahydro-2H-pyran-4-carbonitrile, 4-(4-fluorophenyl)-; 4-(4-Fluorophenyl)-4-cyanotetrahydropyran; 4-(p-Fluorophenyl)-4-cyanotetrahydropyran; 4-(4-Fluorophenyl)-4-cyanooxane; 4-(4-Fluorophenyl)oxane-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 4-(4-Fluorophenyl)Tetrahydro-2H-Pyran-4-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.