Description

3H-1,2,4-Triazol-3-One, 5-(Difluoromethyl)-1,2-Dihydro- (9Ci) is a specialized heterocyclic organic compound featuring a difluoromethyl-substituted triazolone core structure. This high-purity intermediate is critical for advanced synthesis in pharmaceutical and agrochemical research, where its unique fluorinated scaffold enables the development of novel bioactive molecules. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for constructing complex active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of next-generation fungicides and herbicides, where the difluoromethyl group can enhance biological activity and environmental stability.
• Chemical Biology Probe Synthesis: Employed in medicinal chemistry to create selective enzyme inhibitors or receptor modulators for target validation studies.
• Material Science Precursor: Investigated as a monomer or cross-linking agent for the development of specialty polymers with unique thermal or chemical resistance properties.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production under current Good Manufacturing Practice (cGMP) guidelines where required.

Basic Information

Product Name	3H-1,2,4-Triazol-3-One, 5-(Difluoromethyl)-1,2-Dihydro- (9Ci)
CAS No.	461436-82-8
Molecular Formula	C3H3F2N3O
Molecular Weight	147.07 g/mol
Synonyms	5-(Difluoromethyl)-1,2-dihydro-3H-1,2,4-triazol-3-one; 5-(Difluoromethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one; 1,2-Dihydro-5-(difluoromethyl)-3H-1,2,4-triazol-3-one; 5-Difluoromethyl-1,2-dihydro-3H-1,2,4-triazol-3-one; 461436-82-8; 3H-1,2,4-Triazol-3-one, 5-(difluoromethyl)-1,2-dihydro-; DFMT
EINECS	Contact for details

Quality Control

Our 3H-1,2,4-Triazol-3-One, 5-(Difluoromethyl)-1,2-Dihydro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets exacting R&D and production standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results for purity, residual solvents, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.