Description

4-Amino-Chroman-3-Ol is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its unique fused benzopyran structure with amino and hydroxyl functional groups makes it a versatile precursor for the synthesis of complex bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly those focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of potential central nervous system (CNS) active drugs, antidepressants, and neuroprotective agents.
• Organic Synthesis Building Block: Utilized in asymmetric synthesis and medicinal chemistry for constructing complex heterocyclic compounds and natural product analogs.
• Research & Development (R&D): Serves as a critical reference standard and starting material in academic and industrial R&D labs for pharmacological studies and new chemical entity (NCE) discovery.
• Agrochemical Intermediates: Potential use in the synthesis of advanced, bioactive crop protection agents due to its structural motif.
• Catalyst and Ligand Development: The amino and hydroxyl groups can be modified to create novel chiral ligands for asymmetric catalysis.

Basic Information

Product Name	4-Amino-Chroman-3-Ol
CAS No.	454679-90-4
Molecular Formula	C9H11NO2
Molecular Weight	165.19 g/mol
Synonyms	4-Amino-3-hydroxy-3,4-dihydro-2H-1-benzopyran; 3,4-Dihydro-3-hydroxy-4-amino-2H-1-benzopyran; 4-Aminochroman-3-ol; 3-Hydroxy-4-aminochroman; 2H-1-Benzopyran-3-ol, 4-amino-3,4-dihydro-; (3R,4R)-4-Aminochroman-3-ol (for specific enantiomer); (3S,4S)-4-Aminochroman-3-ol (for specific enantiomer)
EINECS	Contact for details

Quality Control

Our 4-Amino-Chroman-3-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), chiral excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grade)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.