Description

2H-Thiopyran-3,4-Diol, Tetrahydro-5-Methyl-, (3R,4R,5S)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its value lies in its unique thiopyran diol structure, which serves as a versatile precursor for constructing complex molecules with precise three-dimensional control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for applications requiring specific stereochemistry, such as the synthesis of novel active pharmaceutical ingredients (APIs) and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, including enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the construction of chiral active ingredients for herbicides, fungicides, and insecticides, where stereochemistry impacts biological activity.
• Catalyst & Ligand Development: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry, particularly in exploring new sulfur-containing heterocycle transformations.
• Material Science Research: Potential building block for developing novel monomers or functional materials with specific optical or electronic properties.

Basic Information

Product Name	2H-Thiopyran-3,4-Diol, Tetrahydro-5-Methyl-, (3R,4R,5S)- (9Ci)
CAS No.	451478-21-0
Molecular Formula	C6H12O2S
Molecular Weight	148.22 g/mol
Synonyms	(3R,4R,5S)-5-Methyltetrahydro-2H-thiopyran-3,4-diol; Tetrahydro-5-methyl-2H-thiopyran-3,4-diol, (3R,4R,5S)-; (3R,4R,5S)-5-Methyltetrahydro-2H-thiopyran-3,4-diol; 451478-21-0; Chiral thiopyran diol; 5-Methyltetrahydro-2H-thiopyran-3,4-diol (stereoisomer); (3R,4R,5S)-rel-5-Methyltetrahydro-2H-thiopyran-3,4-diol
EINECS	Contact for details

Quality Control

Our production of 2H-Thiopyran-3,4-Diol, Tetrahydro-5-Methyl-, (3R,4R,5S)- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized using advanced analytical techniques, including chiral HPLC, NMR, and mass spectrometry, to confirm identity, stereochemical purity, and chemical assay. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development projects with custom purity grades and can align with cGMP standards for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.