Description

2H-1-Benzopyran-4-Carboxylicacid,4-Amino-3,4-Dihydro-2-Oxo-,(-)-(9Ci) CAS NO 442856-11-3 is a high-purity, single-enantiomer chiral building block belonging to the benzopyran class of heterocyclic compounds. This compound is of significant commercial interest due to its role as a key synthetic intermediate in the development of optically active pharmaceuticals and agrochemicals. It is primarily sought by R&D and process development teams in the pharmaceutical, fine chemical, and advanced material sectors for constructing complex molecular architectures with defined stereochemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system and cardiovascular diseases.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators where specific stereochemistry is essential for bioactivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts used in stereoselective transformations.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to introduce the benzopyran scaffold, which is a common motif in flavors, fragrances, and functional materials.
• Academic & Industrial R&D: A valuable compound for methodological studies in organic chemistry, including new route development and stereochemistry research.

Basic Information

Item	Details
Product Name	2H-1-Benzopyran-4-Carboxylicacid,4-Amino-3,4-Dihydro-2-Oxo-,(-)-(9Ci)
CAS No.	442856-11-3
Molecular Formula	C10H9NO4
Molecular Weight	207.18 g/mol
Synonyms	(-)-4-Amino-3,4-dihydro-2-oxo-2H-1-benzopyran-4-carboxylic acid; (4S)-4-Amino-3,4-dihydro-2-oxo-2H-chromene-4-carboxylic acid; 4-Amino-3,4-dihydro-2-oxo-2H-chromene-4-carboxylic acid, (-)-; 442856-11-3; 2H-1-Benzopyran-4-carboxylic acid, 4-amino-3,4-dihydro-2-oxo-, (-)-; (9CI); SCHEMBL21842427; (4S)-4-Amino-3,4-dihydro-2-oxochromene-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems. Every batch is characterized using advanced analytical techniques including chiral HPLC, NMR, and mass spectrometry to ensure high enantiomeric excess (ee) and chemical purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.