Description

D-β-Homoproline-Hcl CAS NO 439918-59-9 is a high-purity, non-proteinogenic amino acid derivative, specifically the hydrochloride salt of the D-enantiomer of β-homoproline. This compound serves as a critical chiral building block and intermediate in advanced pharmaceutical synthesis and peptide research. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, peptidomimetics, and other bioactive molecules.
• Peptide Chemistry: Used to introduce conformational constraints or modify the backbone structure in novel peptide-based drug candidates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective organic synthesis.
• Biochemical Research: A tool compound for studying enzyme-substrate interactions, particularly with proline-specific enzymes.
• Ligand Development: Useful in the design and synthesis of chelating agents or catalysts.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	D-β-Homoproline-Hcl
CAS No.	439918-59-9
Molecular Formula	C6H11NO2 • HCl
Molecular Weight	165.62 g/mol (Free base: 129.16 g/mol)
Synonyms	(2R)-2-Carboxypyrrolidine hydrochloride; D-2-Piperidinecarboxylic acid hydrochloride; (R)-Pipecolic acid hydrochloride; D-Homoproline hydrochloride; D-Pipecolic acid HCl; (R)-2-Piperidinecarboxylic acid hydrochloride; D-2-Carboxypiperidine hydrochloride; (R)-(-)-Pipecolic acid hydrochloride
EINECS	Contact for details

Quality Control

Our D-β-Homoproline-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing specific results for identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.