Description

4-[(2,2,3,3-Tetrafluoropropoxy)Methyl]Benzohydrazide is a high-value, fluorinated organic intermediate with a unique benzohydrazide core functionalized with a tetrafluoropropoxy side chain. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceuticals and agrochemicals, where the introduction of fluorine atoms is a key strategy to modulate bioactivity, metabolic stability, and lipophilicity. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorinated moiety enhances product efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Investigated as a monomer or additive for creating fluorinated polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a building block for fluorescent tags or photoaffinity labels.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex fluorinated intermediates.

Basic Information

Product Name	4-[(2,2,3,3-Tetrafluoropropoxy)Methyl]Benzohydrazide
CAS No.	438473-25-7
Molecular Formula	C11H12F4N2O2
Molecular Weight	280.22 g/mol
Synonyms	4-[(2,2,3,3-Tetrafluoropropoxy)methyl]benzoic acid hydrazide; p-[(2,2,3,3-Tetrafluoropropoxy)methyl]benzohydrazide; Benzoic acid, 4-[(2,2,3,3-tetrafluoropropoxy)methyl]-, hydrazide; 4-(2,2,3,3-Tetrafluoropropoxymethyl)benzohydrazide; Benzohydrazide, 4-[(2,2,3,3-tetrafluoropropoxy)methyl]-; 438473-25-7; SCHEMBL23833027
EINECS	Contact for details

Quality Control

Our production of 4-[(2,2,3,3-Tetrafluoropropoxy)Methyl]Benzohydrazide adheres to a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our facility operates under cGMP principles where applicable, ensuring traceability and compliance for demanding pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.