Description

3-(2,2-Dimethyl-Tetrahydro-Pyran-4-Yl)-4-Phenyl-Butyric Acid is a specialized organic acid building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key chiral intermediate in the production of complex, high-value active pharmaceutical ingredients (APIs) and fine chemicals. Pharmaceutical R&D teams and fine chemical manufacturers need it for developing new therapeutic agents, particularly where specific stereochemistry and molecular architecture are critical for biological activity.

Application

• Pharmaceutical Intermediate: A crucial chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Asymmetric Synthesis: Used in catalytic and stoichiometric asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, agrochemicals, and advanced materials requiring precise molecular frameworks.
• Process Chemistry Development: Utilized for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for the custom synthesis of client-specific molecules and development compounds.

Basic Information

Product Name	3-(2,2-Dimethyl-Tetrahydro-Pyran-4-Yl)-4-Phenyl-Butyric Acid
CAS No.	423736-95-2
Molecular Formula	C17H24O3
Molecular Weight	276.37 g/mol
Synonyms	3-(2,2-Dimethyltetrahydro-2H-pyran-4-yl)-4-phenylbutanoic acid; 4-Phenyl-3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)butyric acid; 3-(2,2-Dimethyl-4-tetrahydropyranyl)-4-phenylbutyric acid; 3-(2,2-Dimethyltetrahydropyran-4-yl)-4-phenylbutanoic acid; 423736-95-2; Butanoic acid, 3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-phenyl-
EINECS	Contact for details

Quality Control

Our 3-(2,2-Dimethyl-Tetrahydro-Pyran-4-Yl)-4-Phenyl-Butyric Acid is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the exacting standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled in accordance with good laboratory practices for strong acids/organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.