Description

4-Bromo-1-(Triisopropylsilyl)-1H-Indole CAS NO 412048-44-3 is a high-value, organosilicon-protected indole derivative. This compound serves as a crucial synthetic intermediate, offering a protected nitrogen site and a reactive bromine handle for selective functionalization in complex molecule assembly. It is primarily required by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging the indole scaffold's bioactivity.
• Material Science Research: Serves as a precursor for organic semiconductors, ligands for catalysts, and other functional organic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Directed Metalation: The triisopropylsilyl (TIPS) group directs ortho-metalation, enabling further regioselective functionalization of the indole ring.
• Academic & Contract Research: Essential reagent in university laboratories and CROs (Contract Research Organizations) for methodological development and library synthesis.

Basic Information

Product Name	4-Bromo-1-(Triisopropylsilyl)-1H-Indole
CAS No.	412048-44-3
Molecular Formula	C17H26BrNSi
Molecular Weight	352.39 g/mol
Synonyms	1H-Indole, 4-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-; 4-Bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indole; 4-Bromo-1-(tert-butyldimethylsilyl)-1H-indole (common error/related compound); 4-Bromo-1-TIPS-indole; TIPS-4-Br-indole; 4-Bromoindole, 1-TIPS protected; 1-Triisopropylsilyl-4-bromo-1H-indole; 4-Br-1-TIPS-Indole
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-(Triisopropylsilyl)-1H-Indole is produced and analyzed under strict quality management protocols. We guarantee high chemical purity and identity confirmed by multiple analytical techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request to ensure compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as oxidizing agents. The container must be kept tightly closed in a dry and inert atmosphere to maximize shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.