Description

Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-formyl- (9Ci) is a highly functionalized, strained bicyclic building block of significant interest in modern organic synthesis and medicinal chemistry. Its unique three-dimensional, rigid scaffold and dual reactive sites (carboxylic acid and aldehyde) make it a valuable precursor for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as fragment-based drug discovery and the synthesis of novel bioisosteres.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for creating sp3-rich, three-dimensional molecules with improved pharmacokinetic properties.
• Bioisostere Development: The bicyclo[1.1.1]pentane (BCP) core is a valuable, rigid bioisostere for a tert-butyl group or a phenyl ring, enabling medicinal chemists to modulate lipophilicity, metabolic stability, and solubility in drug candidates.
• Agrochemical Research: Used in the research and development of new herbicides, fungicides, and insecticides, where its unique geometry can lead to novel modes of action.
• Material Science & Polymer Chemistry: Acts as a specialty monomer or cross-linking agent for creating polymers with tailored mechanical and thermal properties.
• Ligand & Catalyst Synthesis: Employed in the development of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Useful for synthesizing molecular probes to study protein-ligand interactions and biological pathways.

Basic Information

Item	Details
Product Name	Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-formyl- (9Ci)
CAS No.	406947-35-1
Molecular Formula	C7H8O3
Molecular Weight	140.14 g/mol
Synonyms	3-Formylbicyclo[1.1.1]pentane-1-carboxylic acid; 1-Carboxy-3-formylbicyclo[1.1.1]pentane; BCP-COOH-CHO; 3-Formyl-BCP-1-carboxylic acid; [1.1.1]Propellane-3-carboxylic acid, 1-formyl-; Bicyclo[1.1.1]pentane-1,3-dicarboxaldehyde (tautomeric form); 1,3-BCP-dicarboxylic acid (monoaldehyde)
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-formyl- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports your research and development needs with reliable, high-purity building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.