Description

n-Methyl-(S)-1-Ferrocenyl-(R)-(2-Diphenylphosphino)Ethylamine is a chiral ferrocenyl phosphine ligand, a sophisticated organometallic compound designed for asymmetric catalysis. This compound matters because it provides a highly effective and selective framework for creating chiral environments in transition metal-catalyzed reactions, which is critical for synthesizing enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as asymmetric hydrogenation, cross-coupling, and hydroformylation.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the production of enantiomerically pure pharmaceutical intermediates.
• Catalyst component in asymmetric cross-coupling reactions to form carbon-carbon and carbon-heteroatom bonds with high stereoselectivity.
• Use in asymmetric hydroformylation processes to create chiral aldehydes from prochiral olefins.
• Key reagent in academic and industrial R&D for developing novel catalytic methodologies.
• Employed in the synthesis of chiral active pharmaceutical ingredients (APIs) and agrochemicals.
• Precursor for the development of immobilized or modified chiral catalysts for continuous flow processes.

Basic Information

Product Name	n-Methyl-(S)-1-Ferrocenyl-(R)-(2-Diphenylphosphino)Ethylamine
CAS No.	406681-25-2
Molecular Formula	C26H26FeNP
Molecular Weight	447.31 g/mol
Synonyms	(R)-1-[(S)-2-(N-Methylamino)ethyl]ferrocenyl(diphenyl)phosphine; (R)-1-[(S)-2-(Methylamino)ethyl]ferrocenyl(diphenyl)phosphine; Josiphos SL-M502-1; (R)-(S)-N-Methyl-1-ferrocenylethylamine diphenylphosphine; (R)-1-[(S)-2-(Dimethylamino)ethyl]ferrocenyl(diphenyl)phosphine (common misnomer); Chiral Ferrocenyl Phosphine Ligand; N-Methyl-1-ferrocenylethylamine diphenylphosphine derivative
EINECS	Contact for details

Quality Control

Our n-Methyl-(S)-1-Ferrocenyl-(R)-(2-Diphenylphosphino)Ethylamine is produced under strict quality management protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for catalytic performance. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and elemental analysis to confirm identity, enantiomeric excess, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation and light, prolonged exposure to air or ambient light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Elemental Analysis (C, H, N)	Within theoretical ± 0.4%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.