Description

Silane, Trimethyl[(2R)-Oxiranylethynyl]- (9Ci) is a specialized organosilicon compound featuring a reactive epoxide (oxirane) group and a trimethylsilyl-protected alkyne functionality. This unique bifunctional structure makes it a valuable advanced building block for synthesizing complex molecular architectures in pharmaceutical and materials science research. It is primarily utilized by R&D chemists and process development scientists in the fine chemical, pharmaceutical intermediate, and advanced polymer sectors to introduce silicon-containing, cross-linkable moieties into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for introducing silicon and epoxide groups into potential active pharmaceutical ingredients (APIs), particularly in medicinal chemistry for structure-activity relationship (SAR) studies.
• Cross-linking Agent for Specialty Polymers: Used in the synthesis of silicone-based hybrid polymers, where the epoxide group enables ring-opening polymerization or cross-linking, and the silyl alkyne allows for further functionalization via click chemistry.
• Surface Modification Reagent: Employed to functionalize silica, glass, or metal oxide surfaces, creating thin films with specific chemical reactivity or adhesion properties for advanced coatings.
• Ligand and Catalyst Precursor: Acts as a starting material for developing novel organometallic complexes and catalysts used in asymmetric synthesis and homogeneous catalysis.
• Dendrimer and Macromolecule Synthesis: Utilized as a branching or coupling unit in the convergent or divergent synthesis of complex, well-defined dendritic structures.
• Adhesive and Sealant Formulations: Incorporated into high-performance silicone-based formulations to enhance adhesion to substrates and modify cured material properties.

Basic Information

Product Name	Silane, Trimethyl[(2R)-Oxiranylethynyl]- (9Ci)
CAS No.	406218-45-9
Molecular Formula	C9H16OSi
Molecular Weight	168.31 g/mol
Synonyms	((2R)-Oxiranyl-2-ylethynyl)trimethylsilane; (R)-(-)-3-(Trimethylsilylethynyl)oxirane; (R)-(-)-Glycidyltrimethylsilylacetylene; (R)-3-[(Trimethylsilyl)ethynyl]oxirane; (2R)-2-[(Trimethylsilyl)ethynyl]oxirane; Trimethyl[(2R)-oxiranyl-2-ylethynyl]silane; (R)-(-)-Glycidyl TMS-acetylene
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Optical Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.