Description

2-Chloro-3-Fluoro-5-(Tributylstannyl)Pyridine is a high-value organotin intermediate, specifically a stannylated pyridine derivative, essential for advanced organic synthesis. Its core value lies in enabling efficient cross-coupling reactions, such as Stille couplings, to construct complex heterocyclic frameworks that are difficult to access through other routes. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and scalable production of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for constructing complex pyridine-containing molecules via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific halogenated heterocyclic structures.
• Material Science Research: Serves as a precursor for creating functionalized organic materials, including ligands for catalysis and monomers for specialized polymers.
• Stille Coupling Reagent: Functions as a versatile organotin reagent for transferring the 2-chloro-3-fluoro-5-pyridyl group to various electrophilic partners under mild conditions.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological systems, leveraging its selective reactivity.
• Ligand Synthesis: Acts as a starting material for the preparation of sophisticated nitrogen-containing ligands used in homogeneous catalysis.

Basic Information

Product Name	2-Chloro-3-Fluoro-5-(Tributylstannyl)Pyridine
CAS No.	405556-97-0
Molecular Formula	C17H29ClFNSn
Molecular Weight	420.56 g/mol
Synonyms	5-(Tributylstannyl)-2-chloro-3-fluoropyridine; Tributyl(2-chloro-3-fluoro-5-pyridyl)stannane; 2-Chloro-3-fluoro-5-(tributylstannyl)pyridine; 2-Chloro-3-fluoro-5-pyridyltributyltin; 2-Chloro-3-fluoro-5-tributylstannylpyridine; (2-Chloro-3-fluoropyridin-5-yl)tributylstannane; CAS 405556-97-0
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluoro-5-(Tributylstannyl)Pyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All products undergo rigorous analytical testing, including NMR (1H, 13C, 19F), HPLC, and GC analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95%
Tin (Sn) Content	Contact for details
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.