Description

2H-Pyran-3-Amine,3,6-Dihydro-6-(1-Methylethoxy)-,(3R,6R)-(9Ci) is a chiral, substituted dihydropyran derivative with a stereochemically defined amine functionality. This compound serves as a valuable advanced pharmaceutical intermediate (API) and a versatile chiral building block for the synthesis of complex organic molecules. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and fine chemical sectors for creating novel active ingredients and exploring new synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) or metabolic diseases.
• Agrochemical Synthesis: Used as a precursor in the development of new-generation herbicides, fungicides, or insecticides that require specific stereochemistry for optimal activity.
• Asymmetric Catalysis Research: Employed as a ligand precursor or a chiral scaffold in the development of novel asymmetric catalysts for enantioselective synthesis.
• Fine Chemical Manufacturing: Serves as a building block for the synthesis of specialty chemicals, flavors, fragrances, and other high-value-added products.
• Academic & Contract Research: A critical reagent for medicinal chemistry programs and process chemistry optimization in university labs and CROs/CDMOs.
• Material Science: Potential monomer or modifier in the synthesis of specialized polymers with unique optical or electronic properties.

Basic Information

Item	Details
Product Name	2H-Pyran-3-Amine,3,6-Dihydro-6-(1-Methylethoxy)-,(3R,6R)-(9Ci)
CAS No.	405145-82-6
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(3R,6R)-6-Isopropoxy-3,6-dihydro-2H-pyran-3-amine; (3R,6R)-6-(Isopropoxy)-3,6-dihydro-2H-pyran-3-amine; 6-Isopropoxy-3,6-dihydro-2H-pyran-3-amine, (3R,6R)-; (3R,6R)-6-(1-Methylethoxy)-3,6-dihydro-2H-pyran-3-amine; 405145-82-6; (3R-trans)-6-(1-Methylethoxy)-3,6-dihydro-2H-pyran-3-amine; Chiral Dihydropyran Amine
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization, including chiral purity determination by HPLC, to ensure consistent stereochemical integrity and chemical purity. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and impurity profiles are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.