Description

6-Bromo-3,4-Dihydro-2H-1-Benzopyran-4-Carboxylic Acid is a high-purity, functionalized chromane derivative that serves as a critical chiral building block and synthetic intermediate in advanced organic synthesis. Its value lies in the strategic placement of the bromine substituent and carboxylic acid functionality, enabling precise downstream modifications for creating complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Synthesis: Building block for developing advanced pesticides and herbicides with specific activity profiles.
• Ligand and Catalyst Development: Used to construct chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Intermediate for creating functionalized polymers and organic electronic materials.
• Chemical Biology Probes: Serves as a core structure for developing enzyme inhibitors and molecular probes.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and reference standards.

Basic Information

Product Name	6-Bromo-3,4-Dihydro-2H-1-Benzopyran-4-Carboxylic Acid
CAS No.	405103-26-6
Molecular Formula	C10H9BrO3
Molecular Weight	257.08 g/mol
Synonyms	6-Bromochroman-4-carboxylic acid; 4-Chromanecarboxylic acid, 6-bromo-; 6-Bromo-3,4-dihydro-2H-chromene-4-carboxylic acid; 6-Bromo-4-chromanecarboxylic acid; 6-Bromo-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid; 6-Bromo-4-carboxychromane
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-3,4-Dihydro-2H-1-Benzopyran-4-Carboxylic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, which include data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥98.0% (Total area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.