Description

(R)-1-(tert-Butoxycarbonyl)Piperidin-3-Yl Methanesulfonate is a high-purity chiral building block and pharmaceutical intermediate of significant importance in modern organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the (R)-configured piperidine moiety, a common pharmacophore in medicinal chemistry.
• API Development: Serves as a critical precursor in the research, development, and scale-up production of new chemical entities (NCEs) and generic APIs.
• Process Chemistry: Employed in route scouting and optimization for efficient, scalable manufacturing processes in fine chemical and pharmaceutical production.
• Chemical Biology & Proteomics: Can be used as a scaffold or linker in the design of chemical probes and tools for biological target identification and validation.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and for creating compound libraries for high-throughput screening.

Basic Information

Product Name	(R)-1-(tert-Butoxycarbonyl)Piperidin-3-Yl Methanesulfonate
CAS No.	404577-34-0
Molecular Formula	C12H23NO5S
Molecular Weight	293.38 g/mol
Synonyms	(R)-3-(Methanesulfonyloxy)-1-Boc-piperidine; (R)-1-Boc-3-piperidyl methanesulfonate; (R)-N-Boc-3-Hydroxypiperidine Methanesulfonate Ester; (3R)-1-[(1,1-Dimethylethoxy)carbonyl]-3-piperidinyl methanesulfonate; (R)-1-(tert-Butoxycarbonyl)-3-piperidinol Methanesulfonate; tert-Butyl (3R)-3-[(methylsulfonyl)oxy]piperidine-1-carboxylate; (R)-1-Boc-3-piperidinol Mesylate; BOC-(R)-3-Hydroxypiperidine Mesylate
EINECS	Contact for details

Quality Control

Our (R)-1-(tert-Butoxycarbonyl)Piperidin-3-Yl Methanesulfonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for advanced synthetic applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the stringent requirements of pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to support regulatory filings (e.g., Drug Master Files).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Any individual impurity ≤0.5%; Total impurities ≤1.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.