Description

5-Bromo-2-(Trifluoromethoxy)Benzoic Acid is a high-purity, multi-functional aromatic carboxylic acid building block, valued for its unique combination of bromo and trifluoromethoxy substituents which impart significant electronic and steric properties. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its structure is leveraged to modulate biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances lipophilicity and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for designing novel ligands in transition metal catalysis and organocatalysis due to its electron-withdrawing character.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized as a building block for creating fluorescent tags, photoaffinity labels, and other molecular probes for biochemical research.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	5-Bromo-2-(Trifluoromethoxy)Benzoic Acid
CAS No.	403646-47-9
Molecular Formula	C8H4BrF3O3
Molecular Weight	285.02 g/mol
Synonyms	2-(Trifluoromethoxy)-5-bromobenzoic acid; 5-Bromo-2-(trifluoromethoxy)benzoic acid; Benzoic acid, 5-bromo-2-(trifluoromethoxy)-; 5-Bromo-alpha,alpha,α-trifluoro-o-anisic acid; 5-Bromo-2-trifluoromethoxybenzoic acid; 5-Bromo-2-(trifluoromethoxy)benzenecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-2-(Trifluoromethoxy)Benzoic Acid adheres to stringent quality management protocols. Each batch is analytically verified using advanced techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality systems are designed to support development through to commercial scale, meeting the requirements of ISO 9001 and current Good Manufacturing Practice (cGMP) principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC Area %)	≥99.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.