Description

Cyclopropane, 1-(5-Hexen-1-Ynyl)-2-Methyl-, (1R,2R)-Rel- (9Ci) is a high-value, stereochemically defined cyclopropane derivative featuring both alkenyl and alkynyl functional groups. This compound matters as a sophisticated chiral building block, enabling the synthesis of complex molecular architectures with precise three-dimensional control. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for creating constrained analogs and probing structure-activity relationships.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions, including cycloadditions and cross-coupling, to construct complex natural products and bioactive molecules.
• Medicinal Chemistry Research: Employed in lead optimization and library synthesis to introduce the rigid, three-membered cyclopropane ring, which can improve metabolic stability, potency, and selectivity.
• Agrochemical Development: Used in the synthesis of advanced crop protection agents and pesticides where the specific stereochemistry influences biological activity.
• Material Science Research: Investigated as a monomer or precursor for creating specialized polymers with unique thermal or mechanical properties derived from its strained ring and unsaturated moieties.
• Chemical Biology Probes: Acts as a scaffold for developing molecular probes to study enzyme mechanisms or protein-ligand interactions due to its defined spatial geometry.

Basic Information

Product Name	Cyclopropane, 1-(5-Hexen-1-Ynyl)-2-Methyl-, (1R,2R)-Rel- (9Ci)
CAS No.	403611-08-5
Molecular Formula	C10H14
Molecular Weight	134.22 g/mol
Synonyms	(1R,2R)-rel-1-(5-Hexen-1-ynyl)-2-methylcyclopropane; 1-(5-Hexen-1-ynyl)-2-methylcyclopropane, (1R,2R)-rel-; (1R,2R)-1-(Hex-5-en-1-yn-1-yl)-2-methylcyclopropane; 2-Methyl-1-(5-hexen-1-ynyl)cyclopropane, (1R,2R)-rel-; Chiral Alkynyl-Cyclopropane Building Block; (rel-(1R,2R))-1-(5-Hexen-1-ynyl)-2-methylcyclopropane
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. For this advanced intermediate, quality is assured through chiral purity analysis (e.g., chiral HPLC or GC), structural confirmation (NMR, IR), and stringent control of chemical purity. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Chiral Purity (Chiral GC/HPLC)	≥ 98.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.