Description

4-Iodo-3-Nitro-1H-Pyrazole is a high-purity, halogenated nitroheterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both iodine and nitro substituents on the pyrazole core, makes it a versatile intermediate for constructing complex molecules. This compound is primarily utilized by research institutions and pharmaceutical R&D departments engaged in medicinal chemistry, agrochemical discovery, and materials science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Research: Serves as a precursor in the synthesis of new generation herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Development: Used to create specialized pyrazole-based ligands for transition metal catalysis and coordination chemistry.
• Functional Material Synthesis: Employed in the research and development of advanced organic electronic materials and dyes.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro group allows for further functionalization via substitution reactions, expanding molecular diversity.

Basic Information

Product Name	4-Iodo-3-Nitro-1H-Pyrazole
CAS No.	400753-02-8
Molecular Formula	C3H2IN3O2
Molecular Weight	238.97 g/mol
Synonyms	4-Iodo-3-nitropyrazole; 3-Nitro-4-iodo-1H-pyrazole; 1H-Pyrazole, 4-iodo-3-nitro-; 4-Iodo-3-nitro-1H-pyrazole; 4-Iodo-3-nitropyrazole; 400753-02-8; 3-Nitro-4-iodopyrazole
EINECS	Contact for details

Quality Control

Our 4-Iodo-3-Nitro-1H-Pyrazole is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support custom synthesis and can tailor specifications to meet the stringent requirements of advanced R&D projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.