Description

3β-(Trimethylsiloxy)Androst-5-Ene is a high-purity steroid derivative and a key protected intermediate in organic synthesis. Its primary value lies in enabling precise chemical transformations while safeguarding the reactive 3β-hydroxy group, which is critical for producing complex pharmaceutical and research compounds. This product is essential for manufacturers and research institutions in the pharmaceutical, biotechnology, and fine chemical sectors developing steroid-based active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of steroid-based drugs and hormonal therapies.
• Research & Development: Used in academic and industrial laboratories for investigating new synthetic pathways and creating novel steroid analogs.
• Fine Chemical Synthesis: Serves as a protected precursor for manufacturing high-value specialty chemicals and advanced materials.
• API Development: Integral to the process development and scale-up of new Active Pharmaceutical Ingredients (APIs) within GMP environments.
• Biochemical Research: Employed in studies exploring steroid biochemistry, receptor interactions, and metabolic pathways.

Basic Information

Item	Details
Product Name	3β-(Trimethylsiloxy)Androst-5-Ene
CAS No.	49774-79-0
Molecular Formula	C22H38O2Si
Molecular Weight	362.63 g/mol
Synonyms	Androst-5-en-3β-ol, trimethylsilyl ether; 3β-Trimethylsiloxyandrost-5-ene; 3β-(Trimethylsilyloxy)-5-androstene; 5-Androsten-3β-ol trimethylsilyl ether; Androst-5-en-3β-yloxytrimethylsilane; (3β)-3-(Trimethylsilyloxy)androst-5-ene; TMS-Androstene
EINECS	Contact for details

Quality Control

Our 3β-(Trimethylsiloxy)Androst-5-Ene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects requiring material that meets stringent internal or pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using an inert atmosphere or desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.