Description

n-Tosyl-D-Aspartic Acid is a high-purity, protected derivative of the D-enantiomer of aspartic acid, featuring a tosyl (p-toluenesulfonyl) protecting group on the amine functionality. This compound is a critical chiral building block and intermediate in sophisticated organic synthesis, particularly for the preparation of peptides and peptidomimetics where stereochemical integrity is paramount. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-quality, enantiomerically pure intermediates for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Synthesis: Serves as a protected D-aspartic acid residue in solid-phase and solution-phase peptide synthesis to construct complex peptide sequences.
• Bioconjugation & Linker Chemistry: Utilized in the development of antibody-drug conjugates (ADCs) and other bioconjugates due to its reactive carboxylic acid group.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in asymmetric catalytic reactions and the synthesis of non-proteinogenic amino acids.
• Biochemical Research: Used in enzymatic studies and as a substrate or inhibitor in research targeting aspartic acid-specific processes.
• Fine Chemical Production: Intermediate for manufacturing specialty chemicals, advanced materials, and complex organic molecules.

Basic Information

Product Name	n-Tosyl-D-Aspartic Acid
CAS No.	48176-62-1
Molecular Formula	C11H13NO6S
Molecular Weight	287.29 g/mol
Synonyms	D-2-(4-Methylphenylsulfonamido)succinic acid; (R)-2-[(4-Methylphenyl)sulfonyl]amino]butanedioic acid; N-(p-Toluenesulfonyl)-D-aspartic acid; N-Tosyl-D-aspartic acid; Tos-D-Asp-OH; D-Aspartic acid, N-[(4-methylphenyl)sulfonyl]-; D-Aspartic acid N-tosyl derivative; N-(4-Methylbenzenesulfonyl)-D-aspartic acid
EINECS	Contact for details

Quality Control

Our n-Tosyl-D-Aspartic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.