Description

(S)-2-Hydroxy-4-(Methylthio)Butyric Acid is a high-purity, single-enantiomer organic acid that serves as a key chiral intermediate and nutrient precursor. Its value lies in its role as a direct, bioavailable source of L-methionine activity, offering superior metabolic efficiency compared to racemic mixtures. This compound is essential for manufacturers in the animal nutrition, pharmaceutical, and specialty chemical synthesis sectors seeking to enhance product efficacy and meet stringent purity standards.

Application

• Animal Feed Additive: Primary application as a source of bioavailable methionine activity (hydroxy analogue of methionine, HMTBA) for poultry, swine, and aquaculture nutrition.
• Pharmaceutical Intermediate: Chiral building block for the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals requiring the (S)-configuration.
• Biochemical Research: Used in metabolic studies, enzyme substrate research, and as a standard in analytical method development.
• Cosmetic & Personal Care: Potential ingredient in formulations for skin conditioning and hair care products.
• Chemical Synthesis: Intermediate for producing other sulfur-containing compounds, ligands, and chiral catalysts.

Basic Information

Product Name	(S)-2-Hydroxy-4-(Methylthio)Butyric Acid
CAS No.	48042-96-2
Molecular Formula	C5H10O3S
Molecular Weight	150.20 g/mol
Synonyms	L-2-Hydroxy-4-(Methylthio)Butanoic Acid; (S)-HMTBA; (S)-2-Hydroxy-4-(Methylthio)Butanoic Acid; L-HMTBA; (S)-2-Hydroxy-4-(Methylmercapto)Butyric Acid; (S)-2-Hydroxy-4-(Methylsulfanyl)Butanoic Acid; Methionine Hydroxy Analogue (S-form); 2-Hydroxy-4-(methylthio)butyric acid, (S)-
EINECS	256-254-6

Quality Control

Our (S)-2-Hydroxy-4-(Methylthio)Butyric Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity assays, to ensure it meets the high standards required for nutritional and synthetic applications. Certificates of Analysis (COA) detailing specific results for identity, assay, impurities, and optical rotation are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent caking and degradation. For long-term storage, consider using an inert atmosphere to minimize oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Optical Rotation [α]20/D	-24.0° to -26.0° (c=1 in H2O)
Loss on Drying	≤ 0.5%
Residue on Ignition (Sulfated Ash)	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.