Description

4-Guanidinobenzoic Acid Hydrochloride is a high-purity organic salt derivative of guanidinobenzoic acid, valued for its role as a versatile building block in advanced chemical synthesis. Its significance lies in providing a protected guanidine moiety and a carboxylic acid functional group, enabling precise molecular construction. This compound is primarily needed by research institutions and pharmaceutical developers working on protease inhibitors, peptide mimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel drug candidates, particularly serine protease inhibitors.
• Biochemical Research: Used in proteomics and enzymology studies as a tool compound or a modifier for enzyme active sites.
• Peptide Synthesis: Serves as a protected arginine analogue or a specialized amino acid derivative in solid-phase and solution-phase peptide chemistry.
• Organic Synthesis Building Block: Employed in the construction of complex molecules requiring a guanidine group, such as dyes, ligands, and functional materials.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for studying biological processes.

Basic Information

Product Name	4-Guanidinobenzoic Acid Hydrochloride
CAS No.	42823-46-1
Molecular Formula	C8H9N3O2 • HCl
Molecular Weight	215.63 g/mol (Free base: 179.18)
Synonyms	4-Carboxybenzamidine Hydrochloride; p-Guanidinobenzoic Acid HCl; Benzoic acid, 4-(aminoiminomethyl)-, hydrochloride; 4-(Diaminomethylideneamino)benzoic acid hydrochloride; Guanidinobenzoic Acid HCl; 4-GAB HCl; p-Carbamimidoylbenzoic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Guanidinobenzoic Acid Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from HPLC, NMR, and elemental analysis. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.