Description

Ipa-3 is a selective inhibitor of the p21-activated kinase 3 (PAK3), widely used in life science research for probing PAK-mediated signaling pathways. It offers high target specificity and cell permeability, enabling reliable mechanistic studies in neurobiology, cancer biology, and developmental research. Researchers in academic laboratories, biopharmaceutical R&D centers, and contract research organizations rely on Ipa-3 CAS NO 42521-82-4 for consistent, reproducible pharmacological modulation of PAK3 activity.

Application

• Investigation of PAK3-dependent cytoskeletal reorganization in neuronal growth cone guidance
• In vitro functional studies of PAK3 mutations linked to X-linked intellectual disability
• Target validation in preclinical oncology models where PAK3 overexpression drives tumor progression
• Co-treatment with other kinase inhibitors to assess pathway crosstalk in solid tumor cell lines
• Chemical biology tool for dissecting PAK isoform-specific roles in cell migration and invasion assays
• Control compound in high-throughput screening platforms evaluating novel PAK-targeted therapeutics
• Stabilization of inactive PAK3 conformation for structural biology (e.g., co-crystallization studies)

Basic Information

Product Name	Ipa-3
CAS No.	42521-82-4
Molecular Formula	C20H17NO3
Molecular Weight	319.36 g/mol
Synonyms	IPA-3; 4-(4-Morpholinyl)-2-phenyl-6-(trifluoromethyl)pyrimidine; 4-Morpholino-2-phenyl-6-(trifluoromethyl)pyrimidine; NSC 668394; ML141 analog (structural); PAK3 Inhibitor III; (E)-N-(4-(4-Morpholinyl)-2-phenyl-6-(trifluoromethyl)pyrimidin-5-yl)acetamide; 5-Acetamido-4-morpholino-2-phenyl-6-(trifluoromethyl)pyrimidine
EINECS	600-126-2

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of Ipa-3 are verified for identity (HPLC retention time, IR, NMR), purity (≥98.0% by HPLC), and absence of critical impurities (heavy metals, residual solvents). Testing adheres to ACS Reagent Grade and EP 10.0 guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Single impurity ≤0.5%; Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Solubility	Freely soluble in DMSO; sparingly soluble in ethanol; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.